FISIOGRAFT
SPONGE - POWDER - GEL - TEST CE 0434.
An invasive material for contact with mucous membranes and the periost used in dental and jaw-facial surgery. Products of bone regeneration based on a synthetic co-polymer of poly-glycol and poly-milk acid.

Bio-absorbable poly-milk and poly-glycol polymers

Synthetic, biologically absorbable polymers have been known for a long time. A polymer called FISIOGRAFT invented and used by GHIMAS company for the production of sponge filling of the tooth socket is a co-polymer of 1-d poly-acetic acid and poly-glycol acid. For many years, similar products consisting of poly-milk or poly-glycol acid were used in the form of bone plates, connecting bolts, threads and shaped blades used in repair jaw surgery. They are characterised by a high mass density due to the fact, that they have to perform a precise mechanical function. However, FISIOGRAFT, whether in powder or in the form of a sponge or gel, has a significantly lower density, because its function is only to fill the space in an absorbable manner so that it is permeable for blood and osteocytes. Studies have shown, that theoretical decomposition period of milk or glycol polymers ranges from 5-7 weeks to 2-3 years in case of polymers of poly-milk acid of a high molecular mass. Biological decomposition of the product is influenced by many factors - the place of implantation, patient's age, the condition of his immunity system and the tolerance of the tissues. There are also internal biological factors related to the implanted material, e.g. chemical structure, chemical composition, mass density, presence of short chains, configuration of open surface, morphology and the placement of implantation. The final semi-products of polymer decomposition are carbon dioxide and water, and their decomposition largely depends on the capacity of the material enabling diffusion, thanks to which polymers are hydrated and undergo enzymatic decomposition.

FISIOGRAFT is a fully synthetic co-polymer based on poly-milk and poly-glycol acid, completely free of the risk of cross-contamination with pathological factors such as BSE, viral hepatitis, AIDS and other related diseases, and for this reason it is very recommended to fill bone damages. FISIOGRAFT is a bio-compatible and well-tolerated material due to the fact, that it is re-absorbed and decomposed in the Krebbs cycle. FISIOGRAFT is a material that is easy to model and shape. Three different forms are available, which can be joined with each other, which allows to fill any possible type of bone damage. The choice of using one or more forms depends on doctor's evaluation or the clinical arrangement of surgical repair, which is to be performed.

FISIOGRAFT enables a quicker consolidation of a freshly-created bone tissue without causing tissue inflammation at the beginning or during decomposition process. All the available forms of FISIOGRAFT have the same characteristics, which allows the doctor to treat various surgical situations, which can possibly arise.